壹生资讯-ACC.26丨7场最新突破性临床试验即将揭晓，引领心血管诊疗新趋势

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ACC.26丨7场最新突破性临床试验即将揭晓，引领心血管诊疗新趋势

2026-02-25作者：论坛报木易资讯

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北京时间3月28日至30日，由美国心脏病学会（ACC）举办的心血管领域盛会——ACC.26学术会议将在美国新奥尔良隆重举行。以下内容为目前公布的7场最新突破性临床试验（Late-Breaking Clinical Trials）内容。其中，来自中国南京市第一医院的陈绍良教授将在压轴的LBCT Ⅶ专场报告其团队的重要研究，展现中国学者在国际学术舞台上的影响力。

Late-Breaking Clinical Trials Ⅰ

北京时间：3月28日 23:30-00:30

Ultrasound-Facilitated Catheter-Directed Thrombolysis Vs Anticoagulation Alone For Acute Intermediate-High-Risk Pulmonary Embolism: Primary Results of the HI-PEITHO Randomized Clinical Trial

急性中高危肺栓塞超声辅助导管导向溶栓 vs. 单纯抗凝治疗：HI-PEITHO随机临床试验主要结果

Stavros V. Konstantinides

Outcomes in Patients With Atrial Fibrillation Randomized to Receive Left Atrial Appendage Closure or Oral Anticoagulation: Primary Results of the CHAMPION-AF Clinical Trial

随机接受左心耳封堵术或口服抗凝治疗的房颤患者的结局：CHAMPION-AF临床试验的主要结果

Saibal Kar

Primary Left Ventricular Unloading in Anterior ST-Segment Elevation Myocardial Infarction (STEMI) Without Cardiogenic Shock: Results From the STEMI-Door to Unload Randomized Clinical Trial

无心源性休克前壁ST段抬高型心肌梗死的早期左心室减负荷治疗：STEMI-Door to Unload随机临床试验结果

Navin Kapur

Late-Breaking Clinical Trials Ⅱ

北京时间：3月29日 5:45-6:45

Kardinal: A Phase 2 Study of Tonlamarsen For the Treatment of Uncontrolled Hypertension

KARDINAL研究：评估Tonlamarsen治疗未控制高血压的2期临床试验

Luke Laffin

Evolocumab in Patients Without Significant Atherosclerosis: Results From VESALIUS-CV

依洛尤单抗在无显著动脉粥样硬化患者中的应用：VESALIUS-CV研究结果

Nicholas Marston

Intensive Low-Density Lipoprotein Cholesterol Targeting in Patients With Atherosclerotic Cardiovascular Disease

动脉粥样硬化性心血管疾病患者强化低密度脂蛋白胆固醇目标值设定

Yong-Joon Lee

DASH-Patterned Groceries to Reduce Blood Pressure Among Adults With Treated Hypertension: Results From the GoFreshRx Randomized Clinical Trial

为经治疗的高血压成人提供DASH模式食品以降低血压：GoFreshRx随机临床试验结果

Stephen Paul Juraschek

Late-Breaking Clinical Trials Ⅲ

北京时间：3月29日 22:30-23:30

Controlled Trial of High-Risk Coronary Intervention With Percutaneous Left Ventricular Unloading (CHIP-BCIS3)

高危冠状动脉介入治疗中经皮左心室减负荷技术的对照试验：CHIP-BCIS3研究

Divaka Perera

A Large-Scale, Global Randomized Trial of Coronary Physiology Derived From Conventional Angiography Compared With An Invasive Pressure Wire-Based Approach to Guide Percutaneous Coronary Intervention

一项大规模全球随机试验：比较基于常规造影衍生的冠状动脉生理学与基于有创压力导丝的方法指导经皮冠状动脉介入治疗

Ajay J. Kirtane

A Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina- ORBITA-CTO Trial

稳定型心绞痛患者慢性完全闭塞病变经皮冠状动脉介入治疗的随机、安慰剂对照试验——ORBITA-CTO试验

Sarosh A. Khan

Fractional Flow Reserve or 3d-quantitative Coronary Angiography-Based Vessel-Ffr Guided Revascularization – The Fast Iii Trial

血流储备分数或基于3D定量冠状动脉造影的血管FFR指导血运重建——Fast Ⅲ试验

Joost Daemen

Late-Breaking Clinical Trials Ⅳ

北京时间：3月30日 00:45-1:45

Spironolactone in the Treatment of Heart Failure

螺内酯治疗心力衰竭

Frank Edelmann

Efficacy and Safety of Sotatercept in Combined Post- and Pre-Capillary Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction: Results From the Phase 2 Cadence Trial

Sotatercept在射血分数保留型心力衰竭相关的毛细血管前后混合性肺动脉高压中的疗效与安全性：2期Cadence试验结果

Mardi Gomberg-Maitland

Lung Impedance-Guided Therapy in Heart Failure With Preserved Ejection Fraction: Results of a Randomized Clinical Trial

基于肺阻抗监测指导射血分数保留型心力衰竭治疗：一项随机临床试验结果

Michael Kleiner Shochat

Mavacamten in Symptomatic Adolescent Patients With Obstructive Hypertrophic Cardiomyopathy: Results From the Phase 3 Scout-HCM Trial

Mavacamten用于有症状的青少年梗阻性肥厚型心肌病患者：来自3期Scout-HCM试验的结果

Joseph William Rossano

Late-Breaking Clinical Trials Ⅴ

北京时间：3月30日 6:00-7:00

Redo-Surgery Versus Transcatheter Valve-In-Valve For Mitral Bioprosthetic Dysfunction: The SURVIV Trial

再次外科手术 vs. 经导管瓣中瓣技术治疗二尖瓣生物瓣功能障碍：SURVIV试验

Dimytri Siqueira

Transcatheter Aortic Valve Implantation Without Routine Percutaneous Coronary Intervention: A Randomized Controlled Trial
不常规进行经皮冠状动脉介入治疗的经导管主动脉瓣植入术：一项随机对照试验

Michiel Voskuil

Protect The Head To Head Trial: Randomized Comparison of Emboliner Embolic Protection Catheter Vs. Sentinel Cerebral Protection System During Transcatheter Aortic Valve Replacement

Protect The Head to Head试验：Emboliner栓塞保护导管与Sentinel脑保护系统在经导管主动脉瓣置换术中的随机对比研究

Adam B. Greenbaum

Two-Year Outcomes After Transcatheter Tricuspid Repair Without Cross-over in the Randomized Tri-fr Trial

Tri-Fr随机试验中无交叉治疗的经导管三尖瓣修复术后两年结局

Erwan Donal

Late-Breaking Clinical Trials Ⅵ

北京时间：3月30日 22:30-23:30

Heartline Study: A Decentralized Randomized Trial of Apple Watch and iPhone-Facilitated AF Detection and Cardiovascular Outcomes in Older Adults Without Known Atrial Fibrillation

Heartline研究：一项基于苹果手表与iPhone的无症状老年人房颤筛查及心血管结局分散式随机试验

C. Michael Gibson

Digoxin in Rheumatic Heart Disease: A Multi-Center, Randomized, Double Blind, Placebo-controlled Trial

地高辛用于风湿性心脏病：一项多中心、随机、双盲、安慰剂对照试验

Ganesan Karthikeyan

Discontinuation of β-blocker Therapy in Stabilized Patients After Acute Myocardial Infarction

急性心肌梗死后病情稳定患者停用β受体阻滞剂治疗

Joo-Yong Hahn

Effect of Intensive Triglyceride Lowering With Olezarsen on Progression of Coronary Atherosclerosis: A Coronary Cta Substudy of The Essence-TIMI 73b Randomized Trial

Olezarsen强化降低甘油三酯对冠状动脉粥样硬化进展的影响：Essence-TIMI 73b随机试验的冠状动脉CTA亚组研究

Nicholas Marston

Late-Breaking Clinical Trials Ⅶ

北京时间：3月31日 00:45-1:45

Primary Efficacy and Safety Results From the Phase 3 Sirolimus-Coated Balloon For Infra-inguinal Peripheral Arterial Disease (SirPAD) Trial

西罗莫司涂层球囊治疗腹股沟下外周动脉疾病的3期SirPAD试验主要疗效与安全性结果

Stefano Barco

Intravascular Ultrasound Guidance For Complex High-Risk Indicated Procedures – The Ivus Chip Trial

血管内超声指导复杂高危有指征手术——Ivus Chip试验

Roberto Diletti

Intravascular Ultrasound-Guided Versus Angiography-Guided Percutaneous Coronary Intervention In Unprotected Left Main Coronary Artery Disease – The Optimal Trial

血管内超声引导对比造影引导的经皮冠状动脉介入治疗在无保护左主干冠状动脉疾病中的应用——Optimal试验

Adrian Banning

Ivus Or Angiography Guidance For PCI in Complex Coronary Bifurcation Lesions

复杂冠状动脉分叉病变PCI术中血管内超声或血管造影指导

南京市第一医院陈绍良

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ACC.26丨7场最新突破性临床试验即将揭晓，引领心血管诊疗新趋势

Outcomes in Patients With Atrial Fibrillation Randomized to Receive Left Atrial Appendage Closure or Oral Anticoagulation: Primary Results of the CHAMPION-AF Clinical Trial随机接受左心耳封堵术或口服抗凝治疗的房颤患者的结局：CHAMPION-AF临床试验的主要结果Saibal Kar

Kardinal: A Phase 2 Study of Tonlamarsen For the Treatment of Uncontrolled Hypertension KARDINAL研究：评估Tonlamarsen治疗未控制高血压的2期临床试验Luke Laffin

Evolocumab in Patients Without Significant Atherosclerosis: Results From VESALIUS-CV依洛尤单抗在无显著动脉粥样硬化患者中的应用：VESALIUS-CV研究结果Nicholas Marston

Intensive Low-Density Lipoprotein Cholesterol Targeting in Patients With Atherosclerotic Cardiovascular Disease动脉粥样硬化性心血管疾病患者强化低密度脂蛋白胆固醇目标值设定Yong-Joon Lee

DASH-Patterned Groceries to Reduce Blood Pressure Among Adults With Treated Hypertension: Results From the GoFreshRx Randomized Clinical Trial为经治疗的高血压成人提供DASH模式食品以降低血压：GoFreshRx随机临床试验结果Stephen Paul Juraschek

Controlled Trial of High-Risk Coronary Intervention With Percutaneous Left Ventricular Unloading (CHIP-BCIS3)高危冠状动脉介入治疗中经皮左心室减负荷技术的对照试验：CHIP-BCIS3研究Divaka Perera

A Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina- ORBITA-CTO Trial稳定型心绞痛患者慢性完全闭塞病变经皮冠状动脉介入治疗的随机、安慰剂对照试验——ORBITA-CTO试验Sarosh A. Khan

Fractional Flow Reserve or 3d-quantitative Coronary Angiography-Based Vessel-Ffr Guided Revascularization – The Fast Iii Trial血流储备分数或基于3D定量冠状动脉造影的血管FFR指导血运重建——Fast Ⅲ试验Joost Daemen

Spironolactone in the Treatment of Heart Failure螺内酯治疗心力衰竭Frank Edelmann

Lung Impedance-Guided Therapy in Heart Failure With Preserved Ejection Fraction: Results of a Randomized Clinical Trial基于肺阻抗监测指导射血分数保留型心力衰竭治疗：一项随机临床试验结果Michael Kleiner Shochat

Mavacamten in Symptomatic Adolescent Patients With Obstructive Hypertrophic Cardiomyopathy: Results From the Phase 3 Scout-HCM TrialMavacamten用于有症状的青少年梗阻性肥厚型心肌病患者：来自3期Scout-HCM试验的结果Joseph William Rossano

Redo-Surgery Versus Transcatheter Valve-In-Valve For Mitral Bioprosthetic Dysfunction: The SURVIV Trial再次外科手术 vs. 经导管瓣中瓣技术治疗二尖瓣生物瓣功能障碍：SURVIV试验Dimytri Siqueira

Transcatheter Aortic Valve Implantation Without Routine Percutaneous Coronary Intervention: A Randomized Controlled Trial不常规进行经皮冠状动脉介入治疗的经导管主动脉瓣植入术：一项随机对照试验Michiel Voskuil

Two-Year Outcomes After Transcatheter Tricuspid Repair Without Cross-over in the Randomized Tri-fr TrialTri-Fr随机试验中无交叉治疗的经导管三尖瓣修复术后两年结局Erwan Donal

Digoxin in Rheumatic Heart Disease: A Multi-Center, Randomized, Double Blind, Placebo-controlled Trial地高辛用于风湿性心脏病：一项多中心、随机、双盲、安慰剂对照试验Ganesan Karthikeyan

Discontinuation of β-blocker Therapy in Stabilized Patients After Acute Myocardial Infarction急性心肌梗死后病情稳定患者停用β受体阻滞剂治疗Joo-Yong Hahn

Primary Efficacy and Safety Results From the Phase 3 Sirolimus-Coated Balloon For Infra-inguinal Peripheral Arterial Disease (SirPAD) Trial西罗莫司涂层球囊治疗腹股沟下外周动脉疾病的3期SirPAD试验主要疗效与安全性结果Stefano Barco

Intravascular Ultrasound Guidance For Complex High-Risk Indicated Procedures – The Ivus Chip Trial血管内超声指导复杂高危有指征手术——Ivus Chip试验Roberto Diletti

Ivus Or Angiography Guidance For PCI in Complex Coronary Bifurcation Lesions复杂冠状动脉分叉病变PCI术中血管内超声或血管造影指导南京市第一医院 陈绍良

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