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全球卒中领域的最重要学术盛宴之一国际卒中大会2021(International Stroke Conference 2021, ISC2021)于3月17-19日在美国丹佛举行。中国是全球卒中大国,取栓量在也处于世界领先水平。经过多年的蛰伏,近年国内临床研究突飞猛进,国际顶级期刊越来越多地出现中国取栓研究身影。此次大会有不少国内研究报道,笔者筛选了部分急性缺血性脑卒中取栓的部分研究。它山之石可以攻玉,低头干活之余,抬头看路。向国内的大专家们致敬及学习!
虽然力求全面,但笔者精力有限,可能遗漏了部分国内重要研究,见谅!
摘要44:DEVT研究:直接取栓与桥接取栓在脑卒中疗效的比较
作者:重庆新桥医院 资文杰 李凤利 邱忠明 杨清武 等教授
结论:在发病后4.5h内发生近端前循环闭塞的脑卒中患者中,直接取栓在90天功能独立方面不低于桥接取栓。
洲说取栓:该研究是此次大会中国学者在取栓方面的唯一一篇Oral,DEVT研究由新桥医院牵头,全国33家中心参与,全文已经在JAMA上发表。代表了中国学者对全球取栓的重要贡献。新桥医院目前还有几项大型研究在进行,预祝成功。
Abstract 44: DEVT: Endovascular TreatmentAlone versus Intravenous Alteplase Plus Endovascular Treatment in Stroke
Wenjie Zi, Zhongming Qiu, Fengli Li, HongfeiSang, Weidong Luo, Shuai Liu, Junjie Yuan, Jiaxing Song, Raul G Nogueira and QingwuYang
Conclusions: In stroke patients with proximal anterior circulationocclusions within 4.5 hours from onset, mechanical thrombectomy alone wasnon-inferior to intravenous alteplase followed by mechanical thrombectomy interms of 90-day functional independence. (Funded by the Natural ScienceFoundation of China and others; DEVT chictr.org.cn number,ChiCTR-IOR-17013568.)
急性基底动脉闭塞血管内治疗后一年的结果
重庆新桥医院 李凤利 邱忠明 资文杰 杨清武 等教授
结论:在这项长期随访研究中,血管内治疗对急性基底动脉闭塞患者1年后功能结局有益影响与最初研究中90天时报告的相似。
洲说取栓:这是新桥医院主导的BASILAR研究(主文章已发在JAMA Neurology)的一年后的随访结果。
Abstract P478: One-Year Outcome AfterEndovascular Treatment for Acute Basilar Artery Occlusion
Fengli Li, Hongfei Sang, Jiaxing Song, ZhangbaoGuo, Shuai Liu, Weidong Luo, Junjie Yuan, Zhongming Qiu, Linyu Li, Wenjie Ziand Qingwu Yang
Conclusions and Relevance: In this extendedfollow-up study, the beneficial effect of endovascular treatment on functionaloutcome at 1 year in patients with acute basilar artery occlusion was similarto that reported at 90 days in the original study.
摘要P491:直接或桥接血管内治疗前/后循环脑卒中
北京天坛医院 刘丽萍教授 等
结论:与标准桥接治疗相比,直接血管内治疗6小时内大血管闭塞患者的功能结局无显著差异。桥接治疗可能有利于后循环大血管闭塞患者,但有待进一步研究。
Abstract P491: Direct or BridgingEndovascular Treatment for Stroke Due to Anterior or Posterior
Ximing Nie and Liping Liu
Conclusions: Compared with standardbridging therapy, no significant difference in functional outcomes was observedfor direct EVT in LVO patients treated within 6 hours. Bridging therapy may bepotentially favorable for posterior-circulation LVO, which should be furtherresearched. Trial registry number: ChiCTR1900022154 (www.chictr.org.cn).
摘要P549:急性缺血性卒中患者血管内治疗后小血管疾病总负荷与功能独立性无关
北京天坛医院 刘丽萍教授 等
结论:在接受血管内治疗的大血管闭塞脑卒中患者中,MRI评估的脑小血管疾病总负荷与90天时获得功能独立的可能性无显著相关性。较高的脑小血管疾病总负荷可能不是行血管内治疗临床决策排除的标准。
Abstract P549: Total Small Vessel DiseaseBurden Not Associated With Functional Independence After Endovascular Treatmentin Acute Ischemic Stroke Patients
Lina Zheng, Xinyi Leng, Ximing Nie, HongyiYan, Thomas W Leung and Liping Liu
Conclusions: The total SVD burden asassessed in MRI was not significantly associated with the chance of obtainingfunctional independence at 90 days in LVO-stroke patients receiving EVT. Ahigher total SVD burden may not be an exclusion criteria for clinical decisionfor EVT.
摘要P558:大血管闭塞患者栓塞性卒中的鉴别诊断
复旦华山医院 董强教授 等
结论:在中国人群中,CHESS能够可靠且独立地确定栓塞性是大血管闭塞的原因。
备注: Chinese Embolic Stroke Score (CHESS).There were: age (≥64 years, 1 point), non-smoking history (1 point),non-hypertension history (1 point) , baseline NIHSS (≥14, 1 point) and delaytime>6s volume/delay time>3s volume on perfusion imaging (≥0.23, 2points)
洲说取栓:确定栓塞性质,对于手术策略的选择很有裨益。
Abstract P558: Identification of EmbolicStroke in Patients With Large Vessel Occlusion
Lan Hong, Longting Lin, Gang Li, JianhongYang, Geng Yu, Min Lou, Mark Parsons, Xin Cheng and qiang Dong
Conclusions: In a Chinese population, CHESSreliably and independently identified embolic stroke as the cause of largevessel occlusion.
以上为此次大会64篇oral及873篇Poster Abstracts中笔者筛选的部分中国学者的取栓研究,各位看官还想看什么,或者需要摘要全文,欢迎留言、转发。
来源:卒中论坛(翻译作者:袁正洲)
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